Imagine the scenes: hands out, bogged cuffs, hunters in the African savannah pulled a slow breath when the scenery started. Maybe it’s impala, maybe even an elephant or a giraffe – an animal that you can think is very big to eliminate one archer. But the arrow has a secret weapon: the poison that kills a man. Extract from plants sub-Saharan Africa, this compound prevents the liver, sometimes within minutes.

Surprise: The toxin that stops this heart can be the best choice for male contraception.

At the molecular level, the cause is. Throughout the body, membrane proteins control the outer and outer salts of the cells, which are the main challenges for survival and cell function. Ouabain molecules bond with enzymes used by proteins in this process and prevent interchange.

Ouabain traditionally

affects the heart cells, causing a heart attack. However, earlier this year, the researchers announced that they had changed their molecules to address the enzymes used by the type of protein found only in the sperm.

When enzymes are absorbed and damaging the process of exchange of cells, the sperm will lose the ability of the swim – and the sperm can not beat the egg if it is not approachable. Early research on mice indicates that the drug is safe and effective.

“I was thinking about how to think about male contraceptive agents,” said Gunda Georg, head of the pharmaceutical chemistry department of the University of Minnesota. Georg, author of a study on the potential of contraception from overseas, published in January in the Journal of Medicinal Chemistry. “Nothing changes, everything has been developed normally, but once it’s ejaculated, [sperm] can not be moved again.”

Georg worked on various contraceptive research projects, but was particularly excited about the potential of ending up giving new choices to control pregnancy.”I’m optimistic about this particular approach and project,” he said. “I have a feeling that can be a champion.”

It will take years before male contraceptives are based on pharmacy racks, if not. Scientists have tried to develop male contraceptives for more than forty years, with little to demonstrate their efforts. It’s a tough road, full of death and roads. But a small group of researchers are still looking for a very tough winner.

Do not know

People, our debt to the G.D. Searle & Co. – Great time.The first drug to get FDA approval for hormonal birth control pills, Searle can cause more than half a century for women to control the reproductive system.

Today, nearly 10 million women in the United States in the form of pills and about 80 percent have been used at some point in life. The ability to prevent pregnancy has had a greater female sexual freedom and makes it easier to follow education and career before choosing to start a family.

The people were glad to be able to do so. After all, they have a condom for use, and if people want to do everything, vasectomy is an option.There is no good way, but. In laboratory tests, condoms have a failure rate of only 2%. But in the real world, where condoms are sometimes misused, the rate increases by more than 10 percent.

And when vasectomies are almost 100% effective, they are, for the most part, irreversible. Not many, especially younger ones, are happy to join.

Compare this option to people with the distance they can share with women, who can control them, as pills, patches, strokes, intrauterine devices (IUDs) and more that are available to people who do not want to be pregnant.

Some of the most famous, such as contraceptive pills, act on the hormone balance that regulates menstruation and ultimately prevents the release of mature eggs from the ovary. Given the success of how hormones work for women, researchers have turned many testosterone many times as potential male contraceptives.

The first drug manufacturer to get FDA approval for hormonal birth control pills, G.D. Searle & Co. has allowed women to control the system that was published more than half a century ago


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